Dorret I. Boomsma

Parental age in relation to offspring’s neurodevelopment
Authors: Sabine Veldkamp, Mariëlle Zondervan-Zwijnenburg, Elsje van Bergen, Stefania A. Barzeva, Nathalie Tamayo Martinez, Andrik Becht, Catharina E.M. van Beijsterveldt, Wim Meeus, Susan Branje, Manon Hillegers, Albertine J. Oldehinkel, Herbert Hoijtink, Dorret I. Boomsma, Catharina Hartman,
Issue: 2022
Themes: , ,

Objective: Advanced parenthood increases the risk of severe neurodevelopmental disorders like autism, Down syndrome and schizophrenia. Does advanced parenthood also negatively impact offspring’s general neurodevelopment? Method: We analyzed child-, father-, mother- and teacher-rated attention-problems (N= 38,024), and standardized measures of intelligence (N = 10,273) and educational achievement (N = 17,522) of children from four Dutch population-based cohorts. The … Read more

Investigating the genetic architecture of noncognitive skills using GWAS-by-subtraction
Authors: Perline A. Demange, Margherita Malanchini, Travis T. Mallard, Pietro Biroli, Simon R. Cox, Andrew D. Grotzinger, Elliot M. Tucker-Drob, Abdel Abdellaoui, Louise Arseneault, Elsje van Bergen, Dorret I. Boomsma, Avshalom Caspi, David L. Corcoran, Benjamin W. Domingue, Kathleen Mullan Harris, Hill F. Ip, Colter Mitchell, Terrie E. Moffitt, Richie Poulton, Joseph A. Prinz, Karen Sugden, Jasmin Wertz, Benjamin S. Williams, Eveline L. de Zeeuw, Daniel W. Belsky, K. Paige Harden, Michel G. Nivard,
Issue: 2021
Themes: ,

Little is known about the genetic architecture of traits affecting educational attainment other than cognitive ability. We used genomic structural equation modeling and prior genome-wide association studies (GWASs) of educational attainment (n = 1,131,881) and cognitive test performance (n = 257,841) to estimate SNP associations with educational attainment variation that is independent of cognitive ability. … Read more